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The route was established in 1875 when the Southern Pacific Railroad built the line from its San Pedro Branch to Anaheim. It was extended to Santa Ana in 1877. The Santa Ana and Newport Railway opened an independent line between Santa Ana and Newport Beach in 1898, which was absorbed into the Southern Pacific the following year. The street running segment along Santa Ana Street in Anaheim were established in 1899 as a spur for the Anaheim Orange & Lemon Association. The outer end of the original SP line between Santa Ana and the Stanton Branch was abandoned and the right of way reused for construction of the Santa Ana Freeway in the 1950s.