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Tezacitabine

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Tezacitabine
Names
IUPAC name (2′E)-2′-Deoxy-2′-(fluoromethylidene)cytidine
Systematic IUPAC name 4-Amino-1-pyrimidin-2(1H)-one
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C10H12FN3O4/c11-3-5-8(16)6(4-15)18-9(5)14-2-1-7(12)13-10(14)17/h1-3,6,8-9,15-16H,4H2,(H2,12,13,17)/b5-3+/t6-,8+,9-/m1/s1Key: GFFXZLZWLOBBLO-ASKVSEFXSA-N
  • InChI=1/C10H12FN3O4/c11-3-5-8(16)6(4-15)18-9(5)14-2-1-7(12)13-10(14)17/h1-3,6,8-9,15-16H,4H2,(H2,12,13,17)/b5-3+/t6-,8+,9-/m1/s1Key: GFFXZLZWLOBBLO-ASKVSEFXBD
SMILES
  • OC1O(N2C=CC(N)=NC2=O)/C(1O)=C/F
Properties
Chemical formula C10H12FN3O4
Molar mass 257.221 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒N verify (what is  ?) Infobox references
Chemical compound

Tezacitabine is a ribonucleotide reductase inhibitor. It is a synthetic purine nucleoside analogue with potential antineoplastic activity. It is used in synthetic DNA.

References

  1. Tsimberidou AM, Alvarado Y, Giles FJ (August 2002). "Evolving role of ribonucleoside reductase inhibitors in hematologic malignancies". Expert Rev Anticancer Ther. 2 (4): 437–48. doi:10.1586/14737140.2.4.437. PMID 12647987. S2CID 30047759.


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