| U12 minor spliceosomal RNA | |
|---|---|
 Predicted secondary structure and sequence conservation of U12 | |
| Identifiers | |
| Symbol | U12 |
| Rfam | RF00007 |
| Other data | |
| RNA type | Gene; snRNA; splicing |
| Domain(s) | Eukaryota |
| GO | GO:0000371 GO:0045131 GO:0005693 |
| SO | SO:0000399 |
| PDB structures | PDBe |
U12 minor spliceosomal RNA is formed from U12 small nuclear (snRNA), together with U4atac/U6atac, U5, and U11 snRNAs and associated proteins, forms a spliceosome that cleaves a divergent class of low-abundance pre-mRNA introns. Although the U12 sequence is very divergent from that of U2, the two are functionally analogous.
Structure
The predicted secondary structure of U12 RNA is published,. However, the alternative single hairpin in the 3' end shown here seems to better match the alignment of divergent Drosophila melanogaster and Arabidopsis thaliana sequences. The sequences U12 introns that are spliced out are collected in a biological database called the U12 intron database.
References
- Tarn WY, Steitz JA (April 1997). "Pre-mRNA splicing: the discovery of a new spliceosome doubles the challenge". Trends in Biochemical Sciences. 22 (4): 132–7. doi:10.1016/S0968-0004(97)01018-9. PMID 9149533.
- Shukla GC, Padgett RA (April 1999). "Conservation of functional features of U6atac and U12 snRNAs between vertebrates and higher plants". RNA. 5 (4): 525–38. doi:10.1017/S1355838299982213. PMC 1369779. PMID 10199569.
- Otake LR, Scamborova P, Hashimoto C, Steitz JA (February 2002). "The divergent U12-type spliceosome is required for pre-mRNA splicing and is essential for development in Drosophila". Molecular Cell. 9 (2): 439–46. doi:10.1016/S1097-2765(02)00441-0. PMID 11864616.
External links
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