Van Mierlo is a Dutch toponymic surname, meaning "from Mierlo". People with this surname include:
- Freddie van Mierlo (elected 2024}, politician in England
- Godfried van Mierlo (1518–1587), Dutch Dominican Bishop of Haarlem and Abbot of Egmond
- Hans van Mierlo (1931–2010), Dutch politician, Minister of Foreign Affairs and Deputy Prime Minister
- Toine van Mierlo (1957), Dutch footballer
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