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In enzymology, a xylosylprotein 4-beta-galactosyltransferase (EC 2.4.1.133) is an enzyme that catalyzes the chemical reaction

UDP-galactose + O-beta-D-xylosylprotein ${\displaystyle \rightleftharpoons }$ UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein

Thus, the two substrates of this enzyme are UDP-galactose and O-beta-D-xylosylprotein, whereas its two products are UDP and 4-beta-D-galactosyl-O-beta-D-xylosylprotein.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase. Other names in common use include UDP-D-galactose:D-xylose galactosyltransferase, UDP-D-galactose:xylose galactosyltransferase, galactosyltransferase I, and uridine diphosphogalactose-xylose galactosyltransferase. This enzyme participates in chondroitin sulfate biosynthesis and glycan structures - biosynthesis 1. It employs one cofactor, manganese.

References

• Schwartz NB, Roden L (1975). "Biosynthesis of chondroitin sulfate. Solubilization of chondroitin sulfate glycosyltransferases and partial purification of uridine diphosphate-D-galactose:D-xylose galactosyltrans". J. Biol. Chem. 250 (13): 5200–7. doi:10.1016/S0021-9258(19)41296-9. PMID 1150655.
• Okajima T, Yoshida K, Kondo T, Furukawa K (1999). "Human homolog of Caenorhabditis elegans sqv-3 gene is galactosyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans". J. Biol. Chem. 274 (33): 22915–22918. doi:10.1074/jbc.274.33.22915. PMID 10438455.

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