Zeus (aliases Dmel\Rcd-1r, Rcd-1 related/Rcd-1r, CG9573, Drcd-1r/Drcd-1 related) is a male fertility gene in Drosophila, known especially from D. melanogaster and D. simulans. Zeus arose via a retrotransposition from Caf40, a DNA-binding protein. It differs by 107 amino acid substitutions. It retains approximately 30% of Caf40's DNA-binding sites but over the past perhaps 4-6 million years has acquired another 193. These new binding actions regulate hundreds of downstream reproduction related genes. Disruption of this gene disrupts testicle and sperm development.
References
- ^ "FlyBase Gene Report: Dmel\Rcd-1r". FlyBase. 2021-10-15. Retrieved 2021-10-28.
- ^ Long, Manyuan; VanKuren, Nicholas W.; Chen, Sidi; Vibranovski, Maria D. (2013-11-23). "New Gene Evolution: Little Did We Know". Annual Review of Genetics. 47 (1). Annual Reviews: 307–333. doi:10.1146/annurev-genet-111212-133301. ISSN 0066-4197. PMC 4281893. PMID 24050177.
- ^ Ding, Yun; Zhou, Qi; Wang, Wen (2012-12-01). "Origins of New Genes and Evolution of Their Novel Functions". Annual Review of Ecology, Evolution, and Systematics. 43 (1). Annual Reviews: 345–363. doi:10.1146/annurev-ecolsys-110411-160513. ISSN 1543-592X.
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