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Zoxazolamine

Clinical data
Other names	McN-485
Routes of administration	Oral
Identifiers
IUPAC name 5-Chloro-1,3-benzoxazol-2-amine
CAS Number	61-80-3
PubChem CID	6103
ChemSpider	5878
UNII	9DOW362Q29
KEGG	C13841
ChEBI	CHEBI:35053
ChEMBL	ChEMBL472566
Chemical and physical data
Formula	C7H5ClN2O
Molar mass	168.58 g·mol
3D model (JSmol)	Interactive image
SMILES C1=CC2=C(C=C1Cl)N=C(O2)N
InChI InChI=InChI=1S/C7H5ClN2O/c8-4-1-2-6-5(3-4)10-7(9)11-6/h1-3H,(H2,9,10) Key:YGCODSQDUUUKIV-UHFFFAOYSA-N

Zoxazolamine (INN, USAN, BAN) (brand name Contrazole, Deflexol, Flexin, Miazol, Uri-Boi, Zoxamine, Zoxine) is a muscle relaxant that is no longer marketed. It was synthesized in 1953 and introduced clinically in 1955 but was withdrawn due to hepatotoxicity. One of its active metabolites, chlorzoxazone, was found to show less toxicity, and was subsequently marketed in place of zoxazolamine. These drugs activate IK_Ca channels.

References

1. ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 48–. ISBN 978-1-4757-2085-3.
2. ^ Kar A (1 January 2005). Medicinal Chemistry. New Age International. pp. 185–. ISBN 978-81-224-1565-0.
3. ^ Lowry W (6 December 2012). Forensic Toxicology: Controlled Substances and Dangerous Drugs. Springer Science & Business Media. pp. 166–. ISBN 978-1-4684-3444-6.
4. Offermanns S (14 August 2008). Encyclopedia of Molecular Pharmacology. Springer Science & Business Media. pp. 996–. ISBN 978-3-540-38916-3.

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