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Propantheline bromide: Difference between revisions

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| StdInChIKey = XLBIBBZXLMYSFF-UHFFFAOYSA-M | StdInChIKey = XLBIBBZXLMYSFF-UHFFFAOYSA-M
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'''Propantheline bromide''' (]) is an ] agent used for the treatment of excessive sweating (]), cramps or spasms of the stomach, intestines (gut), or bladder, and involuntary urination (]). It can also be used to control the symptoms of ] (IBS) and similar conditions. This agent can also be used for patients who experience intense ] symptoms while tapering off of ]. '''Propantheline bromide''' (]) is an ] medication used for the treatment of excessive sweating (]), cramps or spasms of the stomach, intestines (gut), or bladder, and involuntary urination (]). It can also be used to control the symptoms of ] (IBS) and similar conditions. This medication can also be used for patients who experience intense ] symptoms while tapering off of ].
<ref>{{cite book|title=Female Urology, Urogynecology, and Voiding Dysfunction| vauthors = Vasavada SP, Appell R, Sand PK, Raz S |publisher=Informa Health Care|year= 2004|ISBN=0-8247-5426-3}}</ref> <ref>{{cite book|title=Female Urology, Urogynecology, and Voiding Dysfunction| vauthors = Vasavada SP, Appell R, Sand PK, Raz S |publisher=Informa Health Care|year= 2004|ISBN=0-8247-5426-3}}</ref>


Latest revision as of 06:01, 13 November 2024

Drug for functional gastrointestinal disorders
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Find sources: "Propantheline bromide" – news · newspapers · books · scholar · JSTOR (March 2009) (Learn how and when to remove this message)
Pharmaceutical compound
Propantheline bromide
Clinical data
Trade namesPro-Banthine, others
AHFS/Drugs.comMonograph
MedlinePlusa684020
Routes of
administration		By mouth
Drug classAntimuscarinic
ATC code
Identifiers
IUPAC name
  • N-isopropyl-N-methyl-N-{2-ethyl}propan-2-aminium bromide
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.000.028 Edit this at Wikidata
Chemical and physical data
FormulaC23H30NO3
Molar mass368.497 g·mol
3D model (JSmol)
SMILES
  • .O=C(OCC(C(C)C)(C(C)C)C)C2c3c(Oc1c2cccc1)cccc3
InChI
  • InChI=1S/C23H30NO3.BrH/c1-16(2)24(5,17(3)4)14-15-26-23(25)22-18-10-6-8-12-20(18)27-21-13-9-7-11-19(21)22;/h6-13,16-17,22H,14-15H2,1-5H3;1H/q+1;/p-1
  • Key:XLBIBBZXLMYSFF-UHFFFAOYSA-M
  (what is this?)  (verify)

Propantheline bromide (INN) is an antimuscarinic medication used for the treatment of excessive sweating (hyperhidrosis), cramps or spasms of the stomach, intestines (gut), or bladder, and involuntary urination (enuresis). It can also be used to control the symptoms of irritable bowel syndrome (IBS) and similar conditions. This medication can also be used for patients who experience intense gastrointestinal symptoms while tapering off of tricyclic antidepressants.

Indications

By relaxing the gut muscle, propantheline can relieve pain in conditions caused by spasm of the muscle in the gut. Relaxing the smooth muscle in the bladder prevents the involuntary spasms that can allow leakage of urine from the bladder in the condition known as enuresis (involuntary urination in adults). Propantheline can also be used to treat excessive sweating because acetylcholine block also reduces secretions such as sweat and tears.

Adverse effects

Side effects of propantheline include tachycardia, constipation, hypersensitivity to light, dry mouth, and urinary retention. This can also be prescribed by dentists for certain patients who salivate excessively. By giving this medication, it becomes easier to do "dry" dentistry.

Mechanism of action

Propantheline is one of a group of antispasmodic medications which work by blocking the action of the chemical messenger acetylcholine, which is produced by nerve cells, to muscarinic receptors present in various smooth muscular tissues, in places such as the gut, bladder and eye. Normally, the binding of acetylcholine induces involuntary smooth muscular contractions.

References

  1. Vasavada SP, Appell R, Sand PK, Raz S (2004). Female Urology, Urogynecology, and Voiding Dysfunction. Informa Health Care. ISBN 0-8247-5426-3.
Drugs for functional gastrointestinal disorders (A03)
Drugs for
functional
bowel
disorders
Antimuscarinics
Tertiary
amino group
Quaternary
ammonium
compounds
Phosphodiesterase
inhibitors
Acting on
serotonin receptors
Other
Belladonna
and derivatives
(antimuscarinics)
Propulsives
Muscarinic acetylcholine receptor modulators
mAChRsTooltip Muscarinic acetylcholine receptors
Agonists
Antagonists
Precursors
(and prodrugs)
See also
Receptor/signaling modulators
Nicotinic acetylcholine receptor modulators
Acetylcholine metabolism/transport modulators
Categories:
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