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Metixene

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Chemical compound Pharmaceutical compound
Metixene
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Legal status
Legal status
  • BR: Class C1 (Other controlled substances)
Identifiers
IUPAC name
  • 1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.023.282 Edit this at Wikidata
Chemical and physical data
FormulaC20H23NS
Molar mass309.47 g·mol
3D model (JSmol)
SMILES
  • CN1CCCC(C1)CC2C3=CC=CC=C3SC4=CC=CC=C24
InChI
  • InChI=1S/C20H23NS/c1-21-12-6-7-15(14-21)13-18-16-8-2-4-10-19(16)22-20-11-5-3-9-17(18)20/h2-5,8-11,15,18H,6-7,12-14H2,1H3
  • Key:MJFJKKXQDNNUJF-UHFFFAOYSA-N
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Metixene (brand names Methixart, CholinFall, Tremonil, Trest), also known as methixene, is an anticholinergic used as an antiparkinsonian agent. It has also been reported to induce incomplete autophagy and cell death in metastatic cancer and brain metastases.

See also

References

  1. Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. Morton IK, Hall JM (1999). "Metixene". Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Dordrecht: Springer Netherlands. p. 178. ISBN 978-94-011-4439-1.
  3. Fares, Jawad (2023). "Metixene is an incomplete autophagy inducer in preclinical models of metastatic cancer and brain metastases". Journal of Clinical Investigation. doi:10.1172/JCI161142. PMC 10721147. PMID 37847564. Retrieved 3 November 2023.


Antiparkinson agents (N04)
Dopaminergics
DA precursors
DA receptor agonists
MAO-B inhibitors
COMT inhibitors
AAAD inhibitors
Anticholinergics
Others
Muscarinic acetylcholine receptor modulators
mAChRsTooltip Muscarinic acetylcholine receptors
Agonists
Antagonists
Precursors
(and prodrugs)
See also
Receptor/signaling modulators
Nicotinic acetylcholine receptor modulators
Acetylcholine metabolism/transport modulators


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