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{{drugbox {{drugbox
| verifiedrevid = 413962947
| IUPAC_name = N-(4-(2-methoxyphenoxy)phenyl)- N-(2,2,2-trifluoroethylsulfonyl)pyrid- 3-ylmethylamine | IUPAC_name = N-(4-(2-methoxyphenoxy)phenyl)- N-(2,2,2-trifluoroethylsulfonyl)pyrid- 3-ylmethylamine
| image = LY-487,379_structure.png | image = LY-487,379_structure.png

Revision as of 23:37, 19 April 2011

Pharmaceutical compound
LY-487,379
Clinical data
ATC code
  • none
Identifiers
IUPAC name
  • N-(4-(2-methoxyphenoxy)phenyl)- N-(2,2,2-trifluoroethylsulfonyl)pyrid- 3-ylmethylamine
PubChem CID
IUPHAR/BPS
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC21H19F3N2O4S
Molar mass452.446 g/mol g·mol
3D model (JSmol)
SMILES
  • c3ncccc3CN(S(=O)(=O)CC(F)(F)F)c2ccc(cc2)Oc1ccccc1OC
  (verify)

LY-487,379 is a drug used in scientific research that acts as a selective positive allosteric modulator for the metabotropic glutamate receptor group II subtype mGluR2. It is used to study the structure and function of this receptor subtype, and LY-487,379 along with various other mGluR2/3 agonists and positive modulators are being investigated as possible antipsychotic and anxiolytic drugs.

See also

References

  1. Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 12852748, please use {{cite journal}} with |pmid=12852748 instead.
  2. Schaffhauser, H.; Rowe, B. A.; Morales, S.; Chavez-noriega, L. E.; Yin, R.; Jachec, C.; Rao, S. P.; Bain, G.; Pinkerton, A. B. (2003). "Pharmacological Characterization and Identification of Amino Acids Involved in the Positive Modulation of Metabotropic Glutamate Receptor Subtype 2". Molecular Pharmacology. 64 (4): 798–810. doi:10.1124/mol.64.4.798. PMID 14500736. {{cite journal}}: |first10= missing |last10= (help); More than one of |author2= and |last2= specified (help); More than one of |author3= and |last3= specified (help); More than one of |author4= and |last4= specified (help); More than one of |author5= and |last5= specified (help); More than one of |author6= and |last6= specified (help); More than one of |author7= and |last7= specified (help); More than one of |author8= and |last8= specified (help); More than one of |author9= and |last9= specified (help)
  3. Poisik, O.; Raju, D. V.; Verreault, M.; Rodriguez, A.; Abeniyi, O. A.; Conn, P. J.; Smith, Y. (2005). "Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus". Neuropharmacology. 49: 57–50. doi:10.1016/j.neuropharm.2005.03.006. PMID 15993439.
  4. Galici, R.; Echemendia, N. G.; Rodriguez, A. L.; Conn, P. J. (2005). "A Selective Allosteric Potentiator of Metabotropic Glutamate (mGlu) 2 Receptors Has Effects Similar to an Orthosteric mGlu2/3 Receptor Agonist in Mouse Models Predictive of Antipsychotic Activity". Journal of Pharmacology and Experimental Therapeutics. 315 (3): 1181–7. doi:10.1124/jpet.105.091074. PMID 16123306.
  5. Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 16368268, please use {{cite journal}} with |pmid=16368268 instead.
  6. Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 17318501, please use {{cite journal}} with |pmid=17318501 instead.
  7. Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 190790739, please use {{cite journal}} with |pmid=190790739 instead.
Glutamate receptor modulators
Ionotropic glutamate receptor modulators
AMPARTooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
KARTooltip Kainate receptor
NMDARTooltip N-Methyl-D-aspartate receptor
Metabotropic glutamate receptor modulators
Group I
mGluR1Tooltip Metabotropic glutamate receptor 1
mGluR5Tooltip Metabotropic glutamate receptor 5
Group II
mGluR2Tooltip Metabotropic glutamate receptor 2
mGluR3Tooltip Metabotropic glutamate receptor 3
Group III
mGluR4Tooltip Metabotropic glutamate receptor 4
mGluR6Tooltip Metabotropic glutamate receptor 6
mGluR7Tooltip Metabotropic glutamate receptor 7
mGluR8Tooltip Metabotropic glutamate receptor 8
See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Glutamate metabolism/transport modulators


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