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Cevimeline

Clinical data
Trade names	Evoxac
AHFS/Drugs.com	Monograph
MedlinePlus	a608025
Pregnancy category	C
Routes of administration	Oral
ATC code	N07AX03 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Protein binding	< 20%
Identifiers
IUPAC name 2-methyspiro (1,3- oxathiolane- 5,3) quinuclidine
CAS Number	107233-08-9
PubChem CID	83898
DrugBank	APRD00224
ChemSpider	75707
UNII	K9V0CDQ56E
KEGG	D07667
ChEMBL	ChEMBL1201267
CompTox Dashboard (EPA)	DTXSID801342027 DTXSID40274384, DTXSID801342027
Chemical and physical data
Formula	C10H17NOS
Molar mass	489.565 g/mol g·mol
3D model (JSmol)	Interactive image
SMILES O1(SC12CN3CCC2CC3)C
InChI InChI=1S/C10H17NOS/c1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11/h8-9H,2-7H2,1H3/t8-,10-/m1/s1 Key:WUTYZMFRCNBCHQ-PSASIEDQSA-N
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Cevimeline (Evoxac) is a parasympathomimetic and muscarinic agonist, with particular effect on M₃ receptors. It is used in the treatment of dry mouth associated with Sjögren's syndrome.

Mechanism of action

By activating the M₃ receptors of the parasympathetic nervous system, cevimeline stimulates secretion by the salivary glands, thereby alleviating dry mouth.

Side effects

Known side effects include nausea, vomiting, diarrhea, excessive sweating, rash, headache, runny nose, cough, drowsiness, hot flashes, blurred vision, and difficulty sleeping.

Contraindications include asthma and angle closure glaucoma.

References

1. Ono M, Takamura E, Shinozaki K; et al. (2004). "Therapeutic effect of cevimeline on dry eye in patients with Sjögren's syndrome: a randomized, double-blind clinical study". Am. J. Ophthalmol. 138 (1): 6–17. doi:10.1016/j.ajo.2004.02.010. PMID 15234277. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
2. MedicineNet: Cevimeline. Accessed 10/12/2007

External links

• Evoxac website

• Muscarinic agonists
• Quinuclidines
• Oxathiolanes
• Spiro compounds