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Deschloroketamine

Legal status
Legal status	CA: Schedule I DE: NpSG (Industrial and scientific use only) UK: Class B Illegal in Latvia
Identifiers
IUPAC name 2-Phenyl-2-(methylamino)cyclohexanone
CAS Number	7063-30-1 hydrochloride: 4631-27-0
PubChem CID	437168
ChemSpider	386687
UNII	B0J1D1S3EI hydrochloride: H3MA78UVN7
ChEMBL	ChEMBL2068808
CompTox Dashboard (EPA)	DTXSID701342024 DTXSID10595730, DTXSID701342024
Chemical and physical data
Formula	C13H17NO
Molar mass	203.285 g·mol
3D model (JSmol)	Interactive image
SMILES CNC1(CCCCC1=O)c2ccccc2
InChI InChI=1S/C13H17NO/c1-14-13(10-6-5-9-12(13)15)11-7-3-2-4-8-11/h2-4,7-8,14H,5-6,9-10H2,1H3 Key:ZAGBSZSITDFFAF-UHFFFAOYSA-N

Deschloroketamine (DXE, DCK, 2'-Oxo-PCM) is a dissociative anesthetic that has been sold online as a designer drug. It has also been proposed for the treatment of bacterial, fungal, viral or protozoal infections and for immunomodulation at doses of 2 mg per day.

Legal status

Deschloroketamine is illegal in Latvia, and is covered by blanket bans in Canada and the UK.

See also

• Ketamine
• 2-Fluorodeschloroketamine
• 3-Fluorodeschloroketamine
• Bromoketamine
• Methoxmetamine
• Trifluoromethyldeschloroketamine
• Rhynchophylline

References

1. Robins EG, Zhao Y, Khan I, Wilson A, Luthra SK, Rstad E (March 2010). "Synthesis and in vitro evaluation of (18)F-labelled S-fluoroalkyl diarylguanidines: Novel high-affinity NMDA receptor antagonists for imaging with PET". Bioorganic & Medicinal Chemistry Letters. 20 (5): 1749–51. doi:10.1016/j.bmcl.2010.01.052. PMID 20138515.
2. US 3254124, Stevens CL, "Aminoketones and methods for their production", published 31 May 1966 
3. Frison G, Zamengo L, Zancanaro F, Tisato F, Traldi P (January 2016). "Characterization of the designer drug deschloroketamine (2-methylamino-2-phenylcyclohexanone) by gas chromatography/mass spectrometry, liquid chromatography/high-resolution mass spectrometry, multistage mass spectrometry, and nuclear magnetic resonance". Rapid Communications in Mass Spectrometry. 30 (1): 151–60. Bibcode:2016RCMS...30..151F. doi:10.1002/rcm.7425. PMID 26661982.
4. "Alerta: descloroketamina vendida como ketamina en Barcelona" (in Spanish). Energy Control. Retrieved 2 October 2015.
5. Villalba J (27 March 2015). "Los efectos desconocidos de la sequía de ketamina" (in Spanish). Vice. Retrieved 2 October 2015.
6. Knibbs J (22 October 2015). "Party-drug testing shows its worth". The Medical Republic.
7. Hájková K, Jurásek B, Čejka J, Štefková K, Páleníček T, Sýkora D, Kuchař M (October 2019). "Synthesis and identification of deschloroketamine metabolites in rats' urine and a quantification method for deschloroketamine and metabolites in rats' serum and brain tissue using liquid chromatography tandem mass spectrometry". Drug Testing and Analysis. 12 (3): 343–360. doi:10.1002/dta.2726. PMID 31670910. S2CID 204975994.
8. DE 4409671, Preiss D, Tatar A, "Use of 2-methylamino-2-phenylcyclohexanone for the treatment of bacterial, fungal, viral or protozoal infections and for immunomodulation", published 23 May 1995 
9. "Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem" [Regulations on Narcotic Drugs, Psychotropic Substances and Precursors Controlled in Latvia] (in Latvian). Ministry of Health of the Republic of Latvia. Archived from the original on 4 March 2016. Retrieved 29 October 2015.

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