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HLA-B serotype
major histocompatibility complex (human), class I, B18
HLA-B18 (B18) is an HLA-Bserotype. The serotype identifies the more common HLA-B*18 gene products. (For terminology help see: HLA-serotype tutorial) B*1801, the most common allele is at highest frequencies in Northern Italy and the Balkans, a peak frequency distribution it shares with B*3501.
Serotype
B*18:06 is one of the four B alleles that reacts with neither Bw4 nor Bw6. The others are B*46:01, B*55:03, and B*73:01.
B18 serotype recognition of Some HLA B*18 allele-group gene products
B*18
B18
Sample
allele
%
%
size (N)
1801
96
1641
1802
90
31
1803
83
29
Allele frequencies
HLA B*1801 frequencies
freq
ref.
Population
(%)
Italy North pop 1
16.7
Croatia
11.3
Georgia Svaneti Svans
11.3
Romanian
11.3
Portugal South
11.2
Singapore Riau Malay
9.9
Bulgaria
9.1
Israel Arab Druse
8.5
Azores Central Islands
8.0
Portugal Centre
8.0
Finland
7.8
Azores Santa Maria and Sao Miguel
7.7
Czech Republic
7.5
India Jalpaiguri Toto
7.5
Iran Baloch
7.1
Philippines Ivatan
7.0
Thailand
6.7
Tunisia
6.7
Portugal North
6.5
Zimbabwe Harare Shona
6.4
Madeira
6.2
Mexico Mestizos
6.1
Kenya
5.9
Belgium
5.1
Morocco Nador Metalsa Class I
5.1
Singapore Javanese Indonesians
5.1
Israel Ashkenazi and Non Ashkenazi Jews
5.0
Uganda Kampala
5.0
Kenya Nandi
4.8
Oman
4.7
Georgia Tbilisi Georgians
4.6
Bulgaria Gipsy
4.5
France South East
4.3
Kenya Luo
4.3
Ireland South
4.2
Russia Arkhangelsk Pomors
4.0
Azores Terceira Island
3.9
Guinea Bissau
3.8
India New Delhi
3.8
Spain Eastern Andalusia Gipsy
3.5
Australia New South Wales
3.4
Georgia Tbilisi Kurds
3.4
Zambia Lusaka
3.4
Cameroon Yaounde
2.7
Senegal Niokholo Mandenka
2.7
Cameroon Beti
2.3
Ivory Coast Akan Adiopodoume
2.3
Sudanese
2.3
Saudi Arabia Guraiat and Hail
2.2
South African Natal Zulu
2.0
Thailand
2.0
India Mumbai Marathas
1.9
New Caledonia
1.9
Papua New Guinea Wanigela
1.5
Cameroon Bamileke
1.3
References
Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC2848993. PMID20356336.
Voorter, CE; van der Vlies, S; Kik, M; van den Berg-Loonen, EM (October 2000). "Unexpected Bw4 and Bw6 reactivity patterns in new alleles". Tissue Antigens. 56 (4): 363–70. doi:10.1034/j.1399-0039.2000.560409.x. PMID11098937.