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KIF12
Identifiers
Aliases	KIF12, kinesin family member 12
External IDs	OMIM: 611278; MGI: 1098232; HomoloGene: 7796; GeneCards: KIF12; OMA:KIF12 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q32 Start 114,086,126 bp End 114,099,291 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 B3 Start 63,083,867 bp End 63,090,368 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas gallbladder right lobe of liver right uterine tube left lobe of thyroid gland right lobe of thyroid gland human kidney mucosa of transverse colon testicle renal medulla Top expressed in right kidney proximal tubule islet of Langerhans human kidney epithelium of small intestine medullary collecting duct efferent ductule embryo yolk sac lumbar spinal ganglion More reference expression data BioGPS n/a
Gene ontology Molecular function microtubule binding microtubule motor activity nucleotide binding ATPase activity ATP binding molecular function Cellular component cytoplasm microtubule extracellular exosome cytoskeleton kinesin complex Biological process microtubule-based movement biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 113220 16552 Ensembl ENSG00000136883 ENSMUSG00000028357 UniProt Q96FN5 Q9D2Z8 RefSeq (mRNA) NM_138424 NM_010616 NM_001317352 RefSeq (protein) NP_612433 NP_001304281 NP_034746 Location (UCSC) Chr 9: 114.09 – 114.1 Mb Chr 4: 63.08 – 63.09 Mb PubMed search
Wikidata
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Kinesin family member 12 (KIF12), also known as kinesin-12, is a human protein encoded by the gene KIF12. It is part of the kinesin family of motor proteins.

Clinical significance

Mutations in KIF12 are associated with cholestatic liver disease.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000136883 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000028357 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Stalke, Amelie; Sgodda, Malte; Cantz, Tobias; Skawran, Britta; Lainka, Elke; Hartleben, Björn; Baumann, Ulrich; Pfister, Eva-Doreen (January 2022). "KIF12 Variants and Disturbed Hepatocyte Polarity in Children with a Phenotypic Spectrum of Cholestatic Liver Disease". The Journal of Pediatrics. 240: 284–291.e9. doi:10.1016/j.jpeds.2021.09.019. PMID 34555379. S2CID 237615302.

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• Genes on human chromosome 9
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