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N-Ethylnorketamine

Clinical data
ATC code	none
Legal status
Legal status	CA: Schedule I DE: NpSG (Industrial and scientific use only) UK: Class B
Identifiers
IUPAC name 2-(2-Chlorophenyl)-2-(ethylamino)cyclohexan-1-one
CAS Number	1354634-10-8
PubChem CID	57483649
ChemSpider	35805667
UNII	TLL3802A3P
CompTox Dashboard (EPA)	DTXSID501030493
Chemical and physical data
Formula	C14H18ClNO
Molar mass	251.75 g·mol
3D model (JSmol)	Interactive image
SMILES Clc2ccccc2C1(NCC)CCCCC1=O
InChI InChI=1S/C14H18ClNO/c1-2-16-14(10-6-5-9-13(14)17)11-7-3-4-8-12(11)15/h3-4,7-8,16H,2,5-6,9-10H2,1H3 Key:ITBBBZIIFJJMDU-UHFFFAOYSA-N

N-Ethylnorketamine (ethketamine, NENK, 2-Cl-2'-Oxo-PCE) is a designer drug which is presumed to have similar properties to ketamine, a dissociative anesthetic drug with hallucinogenic and sedative effects. It has been sold over the internet since around September 2012, and identified in seized drug samples by analytical laboratories in the UK and other European countries.

It is an NMDA receptor antagonist. In mice its antidepressant effects are dependent on activation of AMPA and 5-HT2 receptors, as blocking those abolishes said activity.

Legal Status

As of October 2015 NENK is a controlled substance in the United Kingdom, China, and the US state of Alabama.

References

1. Advisory Council on the Misuse of Drugs (ACMD) Methoxetamine Report (2012)
2. Sayson LV, Botanas CJ, Custodio RJ, Abiero A, Kim M, Lee HJ, et al. (July 2019). "The novel methoxetamine analogs N-ethylnorketamine hydrochloride (NENK), 2-MeO-N-ethylketamine hydrochloride (2-MeO-NEK), and 4-MeO-N-ethylketamine hydrochloride (4-MeO-NEK) elicit rapid antidepressant effects via activation of AMPA and 5-HT2 receptors". Psychopharmacology. 236 (7): 2201–2210. doi:10.1007/s00213-019-05219-x. PMID 30891619. S2CID 253743164.
3. Explanatory Memorandum to the Misuse of Drugs (1971) Amendment Order 2013
4. "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Archived from the original on 1 October 2015. Retrieved 1 October 2015.
5. "Alabama Senate Bill 333 - Controlled substances, Schedule I, additional synthetic controlled substances and analogue substances included in, trafficking in controlled substance analogues, requisite weight increased, Secs. 13A-12-231, 20-2-23 am'd". March 2014. Retrieved 28 September 2015.

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• Drugs not assigned an ATC code
• Arylcyclohexylamines
• 2-Chlorophenyl compounds
• Designer drugs
• Dissociative drugs
• Euphoriants
• Hallucinogen stubs